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This meta-analysis found that risk genes for schizophrenia influence childhood adversities in psychosis, but this gene-environment interaction does not fully explain the relationship.
The authors propose criteria for a consensus definition of clinical recovery for first-episode psychosis which would include affective symptom remission and more reasonable criteria for functioning.
This study investigated the emergence of deliberate self-harm and suicide following an initial diagnosis of psychosis among adolescents and young adult first-episode psychosis patients.
Stopping clozapine treatment is challenging due to the risk of psychotic relapse, as well as the development of withdrawal symptoms, but currently there is no formal guidance on how to do so.
This study assessed the impact of cognitive-behavioral therapy for psychosis on young people at clinically high risk. Can it improve transition rates and psychotic symptoms?
This study measured continuity of antipsychotic treatment in individuals with early phase schizophrenia followed for up to 18 years. What risk factors were associated with interruption of treatment?
This commentary highlights the detrimental impact of stigma and discrimination on youth at clinical high risk for psychosis, stressing the importance of interventions to address this vulnerability.
Are patients with schizophrenia more prone to COVID-19 infection? This study investigated the prevalence of COVID-19 morbidity and mortality in schizophrenic patients compared with controls.
This study compares the long-term real-world effectiveness of sixteen commonly used psychopharmacotherapies in schizoaffective disorder. Which are associated with the best--and worst--outcomes?
This study aimed to assess the efficacy of various psychological interventions for adolescents with psychosis such as cognitive remediation therapy, psychoeducation, family therapy, and group therapy.
Have health outcomes and care differed between hospitalized COVID-19 patients with schizophrenia and patients without a diagnosis of severe mental illness?
This study explored the development of treatment-resistant schizophrenia among patients with first-episode schizophrenia-spectrum disorders. Might early interventions reduce the rate of TRS?
Many studies have shown that major depressive disorder plays a major role in the prognosis of schizophrenia. How prevalent is MDD in these patients, and what factors might influence its occurrence?
Review current thought on multimodal hallucinations--hallucinatory experiences which occur in multiple sensory systems. How prevalent are they, and what are their clinical implications?
Might the intense psychosocial stress associated with a novel, potentially fatal disease along with lockdown restrictions be a trigger for first-episode psychosis?
