What are the Rates of Nonresponse to Current Therapy?
In order to understand refractory EoE, it is critical to understand the response rates to each of the current first-line treatments. The AGA/JTF performed the most recent systematic review that evaluated histologic response rates to therapy, defined as less than 15 eos/hpf at 8 weeks (Table 1). The pooled histologic response rate from 23 observational studies of PPI therapy was 41.7%, 64.9% for corticosteroids based on eight double-blind, placebo-controlled RCTs, and 67.9% for empiric SFED from 10 single-arm observational studies. Patients on diets with fewer food groups eliminated had lower rates of remission. As such, it is estimated that 32--58% of patients will fail first-line treatments for EoE.
Curr Opin Gastroenterol. 2022;38(4):395-401. © 2022 Lippincott Williams & Wilkins