The incidence of brain metastases is increasing due to more advanced imaging modalities, more frequent brain imaging, and improved cancer treatments for metastatic disease. Furthermore, numerous new and effective multimodality brain metastasis therapies have been developed over recent years that have led to both improved survival in patients with brain metastases and better preservation of neurocognitive function. As a result, however, brain metastasis therapies are associated with a greater range of potential side effects than ever before, and clinicians are tasked with the challenge of effectively managing these side effects without compromising cancer outcomes. In this review, we have summarized the major complications from intracranial radiotherapy, neurosurgical resection, and brain metastasis directed systemic therapy and corresponding evidenced-based, modern management principles to guide the practicing oncologist.
Direct infrastructure support was provided by the MD Anderson Cancer Center Support Grant (P30CA016672).
Provenance and Peer Review
This article was commissioned by the Guest Editors (Simon S. Lo, Balamurugan Vellayappan, Kevin Shiue and Jonathan P. S. Knisely) for the series "The Modern Approaches to the Management of Brain Metastases" published in Chinese Clinical Oncology. The article has undergone external peer review.
The authors have completed the Narrative Review reporting checklist. Available at https://cco.amegroups.com/article/view/10.21037/cco-21-90/rc
The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved
Chin Clin Oncol. 2022;11(2):11 © 2022 AME Publishing Company