Management of Complications From Brain Metastasis Treatment

A Narrative Review

Kevin Diao; Alan J. Sosa; Gabriel Zada; Seema Nagpal; Eric L. Chang


Chin Clin Oncol. 2022;11(2):11 

In This Article

Complications After Intracranial Radiotherapy

The definition of CNS toxicity is variably categorized into acute versus late or acute, early-delayed, and late by different sources.[20] The Radiation Therapy Oncology Group (RTOG) defines acute CNS toxicities as those occurring within 90 days of radiation treatment and late CNS toxicities as those occurring after 90 days of treatment.[21] From a radiobiological standpoint, distinct histopathological types of injury have been described in the acute, early-delayed, and late timepoints. Acute injury has been described as occurring within either 30 days after treatment, early-delayed injury as occurring 30 days to 6 months after treatment, and late injury as occurring greater than 6 months after treatment.[22,23] For the purposes of this practical review, we will follow the RTOG definition of acute and late CNS toxicity.