Severe Multisystem Inflammatory Symptoms in 2 Adults After Short Interval Between COVID-19 and Subsequent Vaccination

Elizabeth R. Jenny-Avital; Ruth A. Howe


Emerging Infectious Diseases. 2022;28(5):1017-1020. 

In This Article

Abstract and Introduction


We observed multisystem inflammatory syndrome in 2 older adults in the United States who had received mRNA coronavirus disease vaccine soon after natural infection. We identified 5 similar cases from the Vaccine Adverse Events Reporting System. The timing of vaccination soon after natural infection might have an adverse effect on the occurrence of vaccine-related systemic inflammatory disorders.


The Centers for Disease Control and Prevention (CDC) recommends coronavirus disease (COVID-19) vaccination after natural severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection once acute symptoms resolve. We encountered 2 adults at Jacobi Medical Center (Bronx, NY, USA) who experienced severe febrile multisystem inflammatory illness, fulfilling the original CDC surveillance definition for multisystem inflammatory syndrome in adults (MIS-A),[1] after receiving COVID-19 mRNA vaccination 30 days after natural SARS-CoV-2 infection. We subsequently identified 5 similar cases from the Vaccine Adverse Event Reporting System (VAERS; through October 2021 in hospitalized adults >30 years of age.