Multivitamin/Mineral Supplementation Tied to Modest Reduction in CVD Risk

Pavankumar Kamat

Disclosures

March 25, 2022

Takeaway

  • Habitual intake of multivitamin/mineral supplements was associated with very modest reductions in the risk of total cardiovascular disease (CVD) events, individual CVD mortality, coronary heart disease (CHD), and myocardial infarction (MI).

  • Age and smoking may modify these associations.

Why This Matters

  • Previous studies have reported inconsistent results regarding the use of multivitamin/mineral supplements in CVD prevention.

Study Design

  • A population-based cohort study included 465,278 participants without CVD (age, 40-69 years), identified from the UK Biobank (2006-2010).

  • Data on multivitamin/mineral supplement use were evaluated using self-reported questionnaires.

  • Funding: National Natural Science Foundation of China and others.

Key Results

  • Overall, 103,687 (22.3%) participants reported the use of habitual multivitamin/mineral supplements.

  • After adjustment for confounders, multivitamin/mineral supplement use was linked to a modest reduction in (adjusted HR [aHR]; 95% CI):

    • CVD events (0.96; 0.93 to 0.99; P=0.01) and CVD mortality (0.93; 0.86 to 1.00; P=0.05);

    • CHD (0.96; 0.93 to 0.99; P=0.008); and

    • MI (0.92; 0.86 to 0.98; P=0.007).

  • No significant association was seen between the use of multivitamin/mineral supplements and (aHR; 95% CI):

    • stroke (1.00; 0.93 to 1.07; P=0.91);

    • ischaemic stroke (0.95; 0.87 to 1.03; P=0.25); and

    • haemorrhagic stroke (1.13; 0.99 to 1.28; P=0.08).

Limitations

  • Detailed information on the formulation, dosage, frequency, and duration of multivitamin/mineral supplement use was not available.

Che B, Zhong C, Zhang R, Wang M, Zhang Y, Han L. Multivitamin/mineral supplementation and the risk of cardiovascular disease: a large prospective study using UK Biobank data. Eur J Nutr. 2022 Mar 18 [Epub ahead of print]. doi: 10.1007/s00394-022-02865-4. PMID: 35301588 View abstract.

Comments

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