Multivitamin/Mineral Supplementation Tied to Modest Reduction in CVD Risk

Pavankumar Kamat


March 25, 2022


  • Habitual intake of multivitamin/mineral supplements was associated with very modest reductions in the risk of total cardiovascular disease (CVD) events, individual CVD mortality, coronary heart disease (CHD), and myocardial infarction (MI).

  • Age and smoking may modify these associations.

Why This Matters

  • Previous studies have reported inconsistent results regarding the use of multivitamin/mineral supplements in CVD prevention.

Study Design

  • A population-based cohort study included 465,278 participants without CVD (age, 40-69 years), identified from the UK Biobank (2006-2010).

  • Data on multivitamin/mineral supplement use were evaluated using self-reported questionnaires.

  • Funding: National Natural Science Foundation of China and others.

Key Results

  • Overall, 103,687 (22.3%) participants reported the use of habitual multivitamin/mineral supplements.

  • After adjustment for confounders, multivitamin/mineral supplement use was linked to a modest reduction in (adjusted HR [aHR]; 95% CI):

    • CVD events (0.96; 0.93 to 0.99; P=0.01) and CVD mortality (0.93; 0.86 to 1.00; P=0.05);

    • CHD (0.96; 0.93 to 0.99; P=0.008); and

    • MI (0.92; 0.86 to 0.98; P=0.007).

  • No significant association was seen between the use of multivitamin/mineral supplements and (aHR; 95% CI):

    • stroke (1.00; 0.93 to 1.07; P=0.91);

    • ischaemic stroke (0.95; 0.87 to 1.03; P=0.25); and

    • haemorrhagic stroke (1.13; 0.99 to 1.28; P=0.08).


  • Detailed information on the formulation, dosage, frequency, and duration of multivitamin/mineral supplement use was not available.

Che B, Zhong C, Zhang R, Wang M, Zhang Y, Han L. Multivitamin/mineral supplementation and the risk of cardiovascular disease: a large prospective study using UK Biobank data. Eur J Nutr. 2022 Mar 18 [Epub ahead of print]. doi: 10.1007/s00394-022-02865-4. PMID: 35301588 View abstract.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.