A Useful Severity Predictor in Muscular Dystrophy?

Tanyatorn Ghanjanasak, DO, for Medscape

March 09, 2022

The study covered in this summary was published on Researchsquare.com as a preprint and has not yet been peer reviewed.

Key Takeaways

  • Peripheral eosinophil count was negatively correlated with the Vignos muscle strength score in pediatric patients with Duchenne muscular dystrophy (DMD) and was found to be a protective factor for muscle strength.

  • Low peripheral eosinophil counts after treatment with prednisone were associated with poor treatment response.

Why This Matters

  • DMD is a fatal hereditary myopathy that is associated with chronic inflammatory reaction and oxidative stress.

  • This study presents peripheral eosinophil counts as a potential laboratory marker to evaluate muscle strength and response to treatment and to predict prognosis.

Study Design

  • Retrospective data on outpatient and inpatient children with DMD at Hunan Children's Hospital were collected from January 1, 2012, to December 31, 2020.

    • Inclusion criteria included patients' being younger than 5 years with verified DMD by genetic testing.

  • Laboratory data collected included routine blood work, myocardial enzyme spectrum, vitamin D3, and C-reactive protein.

  • Participants returned every 3–6 months for follow-up evaluation of muscle strength and development and laboratory evaluation.

Key Results

  • The 145 pediatric participants with DMD were compared to 150 healthy controls.

  • Pediatric participants with DMD had significantly lower peripheral eosinophil counts than healthy controls (P = .031).

  • Peripheral eosinophil count was negatively correlated with the Vignos muscle strength score (P = .032).

  • On univariate logistic regression, peripheral eosinophil counts were lower after prednisone treatment (P = .020).

Limitations

  • The study was limited by the small number of cases identified in retrospective data.

  • Follow-up for this study was only 6 months.

  • Peripheral eosinophil may not accurately represent infiltration level of eosinophils in muscle.

Disclosures

  • The study did not receive any funding.

  • The authors have disclosed no relevant financial relationships.

This is a summary of a preprint research study, "Relationship Between Peripheral Blood Eosinophil Count and the Severity and Prognosis of Children with Duchenne Muscular Dystrophy : A New Potentially Useful Predictor?," by Zhi Jiang from Hunan Children's Hospital and colleagues on Researchsquare.com. It was provided to you by Medscape. This study has not yet been peer reviewed. The full text of the study can be found on Researchsquare.com.

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