Janus Kinase and Tyrosine Kinase Inhibitors in Dermatology

A Review of Their Utilization, Safety Profile and Future Applications

Mojahed M.K. Shalabi, BS; Benjamin Garcia, BS; Kendall Coleman, BS; Alfredo Siller Jr., MD; Austinn Miller, MD; Stephen K. Tyring, MD, PhD


Skin Therapy Letter. 2022;27(1):4-9. 

In This Article


A review of the literature regarding the mechanism of action and efficacy of JAK inhibitors in skin diseases was done by searching the PubMed, Scopus, and EBSCO databases. The following keywords were used to find articles: 'Janus kinase-inhibitors', 'JAK-inhibitors', 'JAK-inhibitors pathway' combined with 'dermatology', 'atopic dermatitis', 'alopecia areata', 'psoriasis', 'dermatomyositis', 'vitiligo', 'side effects', and 'safety'.