Use of RZV in Immunocompromised Adults Aged >19 Years

Future Research and Monitoring Priorities

CDC will monitor adverse events following RZV immunization through VAERS, the Vaccine Safety Datalink, and observational studies. This is particularly important given the heterogeneity of herpes zoster risk within and across immunocompromised groups and the novel adjuvant and high rates of reactogenicity of the vaccine. Limited data for outcomes deemed important by the work group (e.g., possible graft rejection, graft-versus-host-disease, immune-mediated disease) highlight the need for additional research. Additional post-marketing monitoring will include studies conducted by GSK and reported to FDA. Continued monitoring of the impact of the U.S. varicella and herpes zoster vaccination programs on herpes zoster epidemiology will be important to guide future herpes zoster vaccination recommendations.

Acknowledgments
Members of the Advisory Committee on Immunization Practices (ACIP) (2021 ACIP member rosters are available at https://www.cdc.gov/vaccines/acip/committee/members.html); members of the ACIP Herpes Zoster Work Group; Doug Campos-Outcalt, University of Arizona, College of Medicine, Phoenix, Arizona; Rebecca L. Morgan, Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario; Allison Kempe, Laura P. Hurley, Lori A. Crane, Sean T. O'Leary, Michaela Brtnikova, Jessica Cataldi, Brenda L. Beaty, Carol Gorman, Vaccine Policy Collaborative Initiative, University of Colorado, Denver, Colorado; Amanda Cohn, Thomas Clark, Stephanie Bialek, Alexandra Hess, Kai Hong, Tara Jatlaoui, Andrew Kroger, Jessica Leung, Megan C. Lindley, Jessica MacNeil, Mona Marin, Susannah L. McKay, Manisha Patel, Ismael R. Ortega-Sanchez, Jamison Pike, Paul Rota, Megan Wallace, National Center for Immunization and Respiratory Diseases, CDC; Theresa Harrington, John Su, National Center for Emerging and Zoonotic Infectious Diseases, CDC; Joanna Taliano, Office of Library Science, Office of Science, CDC.

ACIP Herpes Zoster Work Group
Camille N. Kotton, Harvard Medical School, Work Group Chair; Lynn Bahta, Minnesota Department of Health; Grace Lee, Stanford University School of Medicine; Paula Ehrlich Agger, Food and Drug Administration; Jeffrey Cohen, National Institutes of Health; Darcie Everett, Food and Drug Administration; Jeffrey Kelman, Centers for Medicare & Medicaid Services; Carol Baker, Infectious Diseases Society of America; Mary Patricia Friedlander, American Academy of Family Practice; Sandra Fryhofer, American Medical Association, American College of Physicians; Elizabeth Rausch-Phung, Association of Immunization Managers; William Schaffner, National Foundation for Infectious Diseases; Kenneth Schmader, American Geriatrics Society; Adam Welch, American Pharmacists Association; Edward Belongia, Center for Clinical Epidemiology & Population Health, Marshfield Clinic Research Institute; Al Benson, Division of Oncology, Northwestern Medicine; Paul Cieslak, Public Health Division, Oregon Health Authority; Jeffrey Curtis, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham; Jay Fishman, Harvard Medical School and Massachusetts General Hospital; Rafael Harpaz, Harpaz Herman Consultants; Kelly Moore, Immunization Action Coalition; Victoria Morrison, Professor of Medicine, University of Minnesota, Staff Physician, Hennepin Health Care; Steven Pergam, Division of Infection Control, Seattle Cancer Care Alliance; Lisa Prosser, Department of Pediatrics, University of Michigan.