Adherence to a Healthy Sleep Pattern Linked to a Lower Risk of CKD

Pavankumar Kamat


January 19, 2022


  • Adherence to an overall healthy sleep pattern was associated with a lower risk of chronic kidney disease (CKD), especially in those without pre-existing hypertension and those aged ≤60 years.

Why this matters

  • Findings emphasise that CKD interventions focusing on sleep behaviours would be more effective at an early age and before the onset of hypertension.

Study design

  • An analysis of 392,218 participants without CKD (age, 37-73 years), identified from the UK Biobank (2006-2010).

  • Funding: Grants from the National Heart, Lung, and Blood Institute and the National Institute of Diabetes and Digestive and Kidney Diseases.

Key results

  • During a mean follow-up of 11.1 years, 18,842 cases of incident CKD were reported.

  • Compared with a poor sleep pattern (score, 0 to 1), a healthy sleep pattern (score, 5) was associated with a lower risk of CKD (adjusted HR [aHR], 0.77; 95% CI, 0.71 to 0.84).

  • Compared with their counterparts, the aHRs (95% CIs) for CKD were:

    • 0.90 (0.88 to 0.93) for sleep of 7-8 hours/day;

    • 0.97 (0.94 to 1.00) for early chronotype;

    • 0.90 (0.87 to 0.93) for no frequent insomnia;

    • 0.99 (0.96 to 1.02) for no frequent snoring; and

    • 0.89 (0.83 to 0.96) for no frequent daytime sleepiness.

  • A healthy sleep pattern (score, 5) vs poor sleep pattern (score, 0 to 1) was strongly associated with a lower risk of CKD in patients without hypertension (aHR, 0.67; 95% CI, 0.57 to 0.80; Pinteraction = 0.003) vs those with hypertension and in patients aged ≤60 years (aHR, 0.73; 95% CI, 0.64 to 0.82; Pinteraction < 0.001) vs their older counterparts.


  • Sleep behaviours were measured only at recruitment.

  • Risk of residual confounding.

Geng T, Li X, Ma H, Heianza Y, Qi L. Adherence to a Healthy Sleep Pattern and Risk of Chronic Kidney Disease: The UK Biobank Study. Mayo Clin Proc. 2022;97(1):68-77. doi: 10.1016/j.mayocp.2021.08.028. PMID: 34996567 View abstract.


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