Unique Strings of Molecules May Predict Variants' Success

By Reuters Staff

January 18, 2022

(Reuters) - Researchers believe they have discovered an important way to identify SARS-CoV-2 variants that are likely to spread.

Looking at 9-unit strings of nucleotides - the building blocks of genes - they found that except for Beta, which did not circulate widely outside of South Africa, each new variant has had more unique strings than the variant that immediately preceded it. The original, or wild, version of the virus had 45 unique so-called 9-mers, the researchers reported on on medRxiv ahead of peer review. Alpha had 109 unique 9-mers, Beta 69, Gamma 122 and Delta 181. The currently dominant Omicron variant has 295.

Many of these stretches of altered polynucleotides have nothing to do with the spike the virus uses to break into cells, which suggests researchers should not focus only on the spike protein, said Venky Soundararajan of Massachusetts-based data analytics company nference. The spike is the target of most current COVID-19 vaccines and antibody treatments.

Soundararajan said a variant circulating in France, called IHU, has more distinct 9-mers than Delta but has been unable to out-compete Omicron. Because IHU has not circulated widely outside of France, he said, populations have not acquired immunity to it, and variants that have yet to emerge in other places may find it "useful" to develop some of the same 9-mer mutations. Vaccine manufacturers should pay attention to IHU's unique nucleotide signatures because there is a good chance they will show up again in future variants, Soundararajan said.

SOURCE: https://bit.ly/34ZuXzC medRxiv, online January 6, 2022.

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