Narrative Review

Pathogenesis, Diagnosis, and Treatment of Sleep-Related Painful Erection

Yutao Wang; Jianzhong Zhang; Hongjun Li


Transl Androl Urol. 2021;10(12):4422-4430. 

In This Article


Current understanding of the pathogenesis of SRPE can be summarized as abnormal androgen elevation, neuroendocrine disorders, psychological and mental abnormalities, lower pain threshold in REM-stage, and obstructive sleep breathing syndrome. According to literature reports, multiple drugs are applied to provide relief for SRPE patients including baclofen and clonazepam However, the long-term use of baclofen is not advisable, and a combination of multiple drug treatments is the main strategy for these patients.

For these reasons, prospective cohort observation studies of currently proposed treatment methods and further investigation of the regulation of central and peripheral nerve signal pathways and pathological regulation mechanisms of SRPE are urgently required.