Criteria for Pediatric Sepsis

A Systematic Review and Meta-Analysis by the Pediatric Sepsis Definition Taskforce

Kusum Menon, MD, MSc; Luregn J. Schlapbach, MD, FCICM, PhD; Samuel Akech, MBChB, MMED, DPhil; Andrew Argent, MBBCh, MD(Paeds); Paolo Biban, MD; Enitan D. Carrol, MBChB, MD; Kathleen Chiotos, MD, MSCE; Mohammod Jobayer Chisti, MBBS, MMed, PhD; Idris V. R. Evans, MD, MSc; David P. Inwald, MB BChir, PhD; Paul Ishimine, MD; Niranjan Kissoon, MD; Rakesh Lodha, MD; Simon Nadel, MRCP; Cláudio Flauzino Oliveira, MD; Mark Peters, MBChB, PhD; Benham Sadeghirad, PharmD, MPH, PhD; Halden F. Scott, MD, MSCS; Daniela C. de Souza, MD; Pierre Tissieres, MD, DSc; R. Scott Watson, MD, MPH; Matthew O. Wiens, PharmD, PhD; James L. Wynn, MD; Jerry J. Zimmerman, MD, PhD; Lauren R. Sorce, RN, PhD


Crit Care Med. 2022;50(1):21-36. 

In This Article


This systematic review rigorously assessed the association of individual variables with development of sepsis in children with infections and the odds of mortality in children with sepsis, severe sepsis, and septic shock. The included studies were from economically diverse regions of the world, populations with diverse underlying conditions, and varying definitions of sepsis. Despite the clinical heterogeneity and limited number of studies for some variables, strong associations with the outcomes of interest were seen for many of the variables assessed, predominantly reflecting measures of organ dysfunction and supporting the inclusion of these variables in the data validation phase of the Pediatric Sepsis Definition Taskforce.