Second-line Interventions for Migraine in the Emergency Department

A Narrative Review

Farnam Kazi MD; Mallika Manyapu MD; Maha Fakherddine MD; Kumelachew Mekuria MD; Benjamin W. Friedman MD, MS

Disclosures

Headache. 2021;61(10):1467-1474. 

In This Article

Conclusion

In conclusion, a variety of medications are likely to be effective for treatment of migraine refractory to first-line medication, though only scant high-quality data are available to inform this decision. For patients with migraine who fail to improve after treatment with a first-line medication, it is reasonable to use an IV NSAID or IV acetaminophen. Alternatively, clinicians adept at performing a GONB may offer this treatment.

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