Osteoarthritis Linked to Higher Risk of Parkinson's Disease

Pavankumar Kamat

Disclosures

December 20, 2021

Takeaway

Why this matters

  • Findings suggest that measures aimed at preventing PD should be implemented in patients with OA.

Study design

  • A retrospective cohort study included participants diagnosed with OA in one of 256 general practices in the United Kingdom (2000-2016).

  • 260,224 patients with OA were matched (1:1) to those without OA using propensity scores.

  • Primary outcome: 10-year cumulative incidence of PD in patients with and without OA.

  • Funding: None.

Key results

  • The 10-year cumulative incidence of PD was higher in patients with OA vs those without (1.2% vs 0.6%; adjusted HR [aHR], 1.82; 95% CI, 1.63-2.02; log-rank P < .001).

  • In sex and age subgroup analysis (aHR; 95% CI):

    • The risk of PD was higher in both women with OA (1.88; 1.61-2.19) and men with OA (1.75; 1.51-2.04; P < .001 for both) vs those without.

    • Similarly, the risk of PD was higher in patients with OA aged (aHR; 95% CI):

      • ≤50 years (3.22; 1.06-9.38; P = .040);

      • 51-60 years (2.12; 1.43-3.14; P < .001);

      • 61-70 years (2.14; 1.72-2.67; P < .001);

      • 71-80 years (1.79; 1.53-2.09; < .001); and

      • >80 years (1.59; 1.27-1.99; P < .001).

  • Based on different types of OA, knee OA (aHR, 2.32; 95% CI, 1.42-3.79) and other and unspecified OA (aHR, 1.85; 95% CI, 1.64-2.08; P < .001 for both) were significantly associated with a higher risk of PD.

Limitations

  • Retrospective design.

Jacob L, Smith L, Koyanagi A, Schnitzler A, Il Shin J, Kostev K. Association between osteoarthritis and the incidence of Parkinson's disease in the United Kingdom. Clin Park Relat Disord. 2021;5:100120. doi: 10.1016/j.prdoa.2021.100120. PMID: 34888519 View Full Text.

Comments

3090D553-9492-4563-8681-AD288FA52ACE
Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.

processing....