Impact of Persistent Subclinical Hypothyroidism on Clinical Outcomes in Non-ST-Segment Elevation Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention

Chuyi Han; Kaihang Xu; Le Wang; Yingyi Zhang; Rui Zhang; Ao Wei; Lijie Dong; Yuecheng Hu; Jinghan Xu; Wenyu Li; Tingting Li; Chunwei Liu; Wei Qi; Dongxia Jin; Jingxia Zhang; Hongliang Cong


Clin Endocrinol. 2022;96(1):70-81. 

In This Article


This study has some limitations. Patients in this study did not undergo anti-thyroid autoantibodies and thyroid ultrasound examination; therefore, some patients with a diagnosis of thyroiditis may have been missed. High calcium and phosphorus products are considered to be a risk factor for patients with CKD, and there was no routine measurement of calcium and phosphorus status in our study. Since the age-adjusted TSH reference range was not included in our study, the prevalence of SCH may have been overestimated. Patients included in the study were required to measure TSH levels before coronary angiography and 1 day and 1 month after coronary angiography. Although there were professionals in this study responsible for notifying patients by telephone and making appointments for reexamination, it was inevitable that some patients failed to complete TSH examination regularly, which may have affected the generalisability of the study. Lastly, the power of our study was calculated by estimating the occurrence of MACCEs and thus, comparisons of the occurrence of each component outcome may be underpowered.