Effect of Atrial Fibrillation on Peripheral Arterial Disease Outcomes

Pavankumar Kamat


December 09, 2021


Why this matters

  • Findings underscore the need for proactive surveillance and optimal management in patients with peripheral arterial disease and AF.

Study design

  • The retrospective study used data from The Health Improvement Network database.

  • 5685 patients with peripheral arterial disease and baseline AF (cases) were matched (1:1) to patients with peripheral arterial disease and without AF, using propensity score matching.

  • Funding: None disclosed.

Key results

  • AF was significantly associated with an increased risk of (adjusted HR [aHR]; 95% CI):

    • mortality (1.18; 1.12-1.26);

    • incident cerebrovascular events (1.35; 1.17-1.57); and

    • heart failure (1.87; 1.62-2.15; P<.01 for all).

  • No significant association was seen between AF and the risk of ischaemic heart disease (aHR, 0.97; 95% CI, 0.81-1.78; P=.78) and limb loss (aHR, 1.06; 95% CI, 0.85-1.32; P=.59).


  • Retrospective design.

Vitalis A, Nirantharakumar K, Thayakaran R, Vohra RK, Kay M, Shantsila A, Lip GYH. THE IMPACT OF ATRIAL FIBRILLATION ON OUTCOMES OF PERIPHERAL ARTERIAL DISEASE: ANALYSIS OF ROUTINELY COLLECTED PRIMARY CARE DATA. Am J Med. 2021 Nov 15 [Epub ahead of print]. doi: 10.1016/j.amjmed.2021.10.021. PMID: 34793748 View abstract.



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