IBD Not Associated with a Higher Risk of Dementia

Pavankumar Kamat


December 08, 2021


Why this matters

  • There is uncertainty regarding the association between IBD and dementia.

Study design

  • An analysis of 497,775 participants from the UK Biobank (2006-2010).

  • The association of IBD and its subtypes with dementia was evaluated.

  • In addition, the association of IBD with brain structure and cognitive function was assessed.

  • Funding: National Natural Science Foundation of China and others.

Key results

  • Of 497,775 participants, 5778 developed dementia.

  • During a mean follow-up of 11.58 years, 100 patients with IBD and 6709 without IBD were diagnosed with dementia.

  • Of 100 patients with IBD, 30 patients with CD and 70 with UC developed dementia.

  • The risk of subsequent dementia was not significantly higher in patients with (adjusted HR; 95% CI):

    • IBD (1.14; 0.94-1.39; P=.182);

    • CD (1.20; 0.84-1.71; P=.329); and

    • UC (1.12; 0.89-1.42; P=.334).

  • No significant association was seen between IBD and measures of brain structure.

  • In terms of cognitive tests performance, patients with IBD vs those without had a significant increase in reaction time (­β, 12.32; 95% CI, 1.97-22.67; P=.020).


  • Study did not evaluate the association of IBD with dementia subtypes because of a small number of dementia cases.

  • Risk of residual confounding.

Sun Y, Geng J, Chen X, Chen H, Wang X, Chen J, Li X, Hesketh T. Association Between Inflammatory Bowel Disease and Dementia: A Longitudinal Cohort Study. Inflamm Bowel Dis. 2021 Nov 29 [Epub ahead of print]. doi: 10.1093/ibd/izab300. PMID: 34849925 View Full Text.



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