The study found no significant association between inflammatory bowel disease (IBD) or its subtypes (Crohn’s disease [CD] and ulcerative colitis [UC]) and the risk of subsequent dementia.
Why this matters
There is uncertainty regarding the association between IBD and dementia.
An analysis of 497,775 participants from the UK Biobank (2006-2010).
The association of IBD and its subtypes with dementia was evaluated.
In addition, the association of IBD with brain structure and cognitive function was assessed.
Funding: National Natural Science Foundation of China and others.
Of 497,775 participants, 5778 developed dementia.
During a mean follow-up of 11.58 years, 100 patients with IBD and 6709 without IBD were diagnosed with dementia.
Of 100 patients with IBD, 30 patients with CD and 70 with UC developed dementia.
The risk of subsequent dementia was not significantly higher in patients with (adjusted HR; 95% CI):
IBD (1.14; 0.94-1.39; P=.182);
CD (1.20; 0.84-1.71; P=.329); and
UC (1.12; 0.89-1.42; P=.334).
No significant association was seen between IBD and measures of brain structure.
In terms of cognitive tests performance, patients with IBD vs those without had a significant increase in reaction time (β, 12.32; 95% CI, 1.97-22.67; P=.020).
Study did not evaluate the association of IBD with dementia subtypes because of a small number of dementia cases.
Risk of residual confounding.
Sun Y, Geng J, Chen X, Chen H, Wang X, Chen J, Li X, Hesketh T. Association Between Inflammatory Bowel Disease and Dementia: A Longitudinal Cohort Study. Inflamm Bowel Dis. 2021 Nov 29 [Epub ahead of print]. doi: 10.1093/ibd/izab300. PMID: 34849925 View Full Text.
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Cite this: Pavankumar Kamat. IBD Not Associated with a Higher Risk of Dementia - Medscape - Dec 08, 2021.