Review Article

Drug-induced Small Bowel Injury

Shadi Hamdeh; Dejan Micic; Stephen Hanauer

Disclosures

Aliment Pharmacol Ther. 2021;54(44512):1370-1388. 

In This Article

Pathophysiology

The small intestine represents one of the most frequent sites for drug injury due to a variety of factors including high luminal drug concentrations, the redundant surface area of the SB and exposure to intraluminal bacteria.[9] The mechanisms by which medications can cause small intestinal injury are complex including direct cytotoxicity to the mucosa (eg potassium chloride), immune suppression (eg cytotoxic treatment for cancer, anti-inflammatory drugs), altered motility (anti-cholinergics effects) or a combination of the aforementioned actions (eg cytotoxic medications).[9]

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