Chronic Fatigue Syndrome and Cardiovascular Disease

JACC State-of-the-Art Review

Benjamin H. Natelson, MD; Danielle L. Brunjes, PHD; Donna Mancini, MD


J Am Coll Cardiol. 2021;78(10):1056-1067. 

In This Article


There are cardiovascular changes that are associated with ME/CFS, such as reduced stroke volume and resting cardiac output, decreased total blood volume, and altered heart rate variability with postural hypotension. These cardiovascular changes may contribute to the symptoms and debilitation associated with this disorder. Further research is needed to assess if and how these cardiovascular changes are associated with the severe fatigue and PEM of ME/CFS and what role deconditioning plays in symptom maintenance over time.