Does Regular Glucosamine Use Lower the Risk of Incident COPD?

Pavankumar Kamat


September 21, 2021


Why this matters

  • Findings indicate that regular glucosamine use combined with smoking cessation may reduce the risk of COPD.

Study details

  • A prospective study assessed the association between regular glucosamine use and incident COPD risk in UK Biobank 483,703 participants (mean age, 56.5 years; males, 54.6%).

  • Funding: National Natural Science Foundation of China and others.

Key results

  • Overall, 19.1% of participants self-reported habitual glucosamine use at baseline.

  • During a median follow-up of 8.96 years, 9016 participants developed incident COPD.

  • Regular glucosamine use was significantly associated with a reduced risk of incident COPD (adjusted HR [aHR], 0.80; 95% CI, 0.75-0.85; P<.001).

  • A significant interaction was observed between glucosamine use and smoking pack-years (P=.019) on the risk of incident COPD:

  • never smokers: aHR, 0.82; P=.003;

  • hardly ever smokers: aHR, 0.78; P=.065;

  • light smokers: aHR, 0.70; P<.001;

  • moderate smokers: aHR, 0.66; P<.001; and

  • heavy smokers: aHR, 0.85; P=.002.

  • Regular glucosamine use could reduce incident COPD events by 83.72% (95% CI, 82.79-84.52%) in never smokers and 25.53% (95% CI, 17.49-32.70%) in current smokers.

  • Regular glucosamine use combined with smoking cessation could reduce incident COPD by 61.74% (95% CI, 59.98-63.30%).


  • Residual confounding bias.

  • Dietary supplement intake was self-reported without detailed information on formulations, dosage, duration and frequency of glucosamine use.  


Zhang XR, Zhang PD, Li ZH, Yang P, Wang XM, Liu HM, Liang F, Wang JD, Sun Y, Shen D, Chen PL, Zhong WF, Huang QM, Liu D, Wang ZH, Kraus VB, Mao C. Glucosamine use, smoking and risk of incident chronic obstructive pulmonary disease: A large prospective cohort study. Br J Nutr. 2021 Sep 16 [Epub ahead of print]. doi: 10.1017/S000711452100372X. PMID: 34526168.  View full text

This clinical summary originally appeared on Univadis, part of the Medscape Professional Network.


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