A Meta-Analysis and Systematic Review of Holmium Laser Treatment of Bladder Stones

Jie Lv; Ning Wang; Yongsheng Zhu; Qian Luo; Yongxian Li; Jian Li


Transl Androl Urol. 2021;10(8):3465-3475. 

In This Article


In this meta-analysis, a total of 10 references were included, comprising 1,642 patients with vesical calculi. The investigation confirmed that compared to pneumatic lithotripsy, holmium laser lithotripsy significantly reduces the incidence of postoperative adverse reactions, shortens surgery time, and lowers the calculus removal rate of patients, and thus demonstrates superior capabilities in treating vesical calculi. However, this study had some limitations that should be noted. First, some articles exhibited large publication biases. Second, the sample size was small, which may have reduced the power of the meta-analysis results. In the future, a high-quality study with an expanded sample size needs to be conducted to further verify the efficacy of holmium laser lithotripsy in the treatment of vesical calculi.