We searched two databases—PubMed and Cochrane—for English-language studies from database inception until June 2020, using the keywords 'colchicine', 'cardiovascular', 'allopurinol', 'febuxostat', 'gout therapy', 'heart failure', and 'major adverse cardiovascular events'. We also searched for meta-analyses, observational studies, practice guidelines, and reviews. Importance was given to randomized controlled trials and recent high-quality reviews.
Am J Cardiovasc Drugs. 2021;21(5):499-512. © 2021 Adis Springer International Publishing AG