Challenges of Dengue and Coronavirus Disease 2019 Coinfection

Two Case Reports

Olga Lucia Agudelo Rojas; Maria Elena Tello-Cajiao; Fernando Rosso


J Med Case Reports. 2021;15(439) 

In This Article


Dengue fever is an endemic arbovirus in tropical and subtropical regions.[1] From 2019 to the present, it has exhibited epidemic behavior worldwide, with approximately 4.2 million cases reported in 2019. In the Americas alone, 3.1 million cases were reported last year, with more than 25,000 classified as severe.[2] On the other hand, severe acute respiratory syndrome coronavirus 2 (SARS CoV-2), which causes coronavirus disease 2019 (COVID-19), was declared a pandemic in March 2020 by the World Health Organization (WHO). It currently has infected approximately 44 million worldwide, and caused more than 1 million deaths.[3] As expected, in 2020, dengue fever and COVID-19 began to overlap, and several dengue-endemic countries, such as Singapore, Thailand, India, and Bangladesh, have already reported coinfection.[4–7]

This situation represents a challenge in the diagnosis and treatment of both infections, given the differences in the transmission mechanisms and their management implications. It is a priority to establish a timely diagnosis of COVID-19 in areas that are also experiencing a dengue epidemic to avoid delays in proper treatment.[6,8] Therefore, laboratory tests play an important role in the clinical field and public health actions to control COVID-19 transmission. In this article, we present and analyze the cases of two patients with symptoms and laboratory findings compatible with dengue fever as well as COVID-19 who were treated in a health institution in Cali, Colombia, in June 2020.