Systematic Review

Hepatitis C Viraemic Allografts to Hepatitis C-negative Recipients in Solid Organ Transplantation

Taaj Raasikh; Taher Jamali; Avegail Flores; Ronald T. Cotton; Venkat Ramanathan; Henkie P. Tan; Ruben Hernaez


Aliment Pharmacol Ther. 2021;54(5):571-582. 

In This Article


Our study of 852 solid organ transplantations from HCV NAT-positive allografts into HCV seronegative recipients showed minimal impact on graft survival, rejection and adverse events. Furthermore, no patient deaths were related to the transmission of HCV, and a high rate of SVR12 was attained due to treatment with DAAs. These results suggest that transplanting organs from HCV viraemic allografts to seronegative recipients could become standard practice for patients who do not have contraindications to DAAs, as this can potentially help to alleviate organ donor shortage.