COPD but Not Asthma Associated with Worse COVID-19 Outcomes

Pavankumar Kamat

Disclosures

August 04, 2021

Takeaway

Why this matters

  • Findings suggest that patients with COPD should take special precautions to lower the risk of COVID-19 exposure.

Study design

  • UK researchers conducted a meta-analysis of 37 studies (n=1,678,992) identified through a literature search across electronic databases.

  • Risks of COVID-19-related hospitalisation, ICU admission and mortality were evaluated in patients with COPD and asthma.

  • Funding: None disclosed.

Key results

  • COPD was associated with an increased risk of COVID-19-related (adjusted OR [aOR]; 95% CI):

    • hospitalisation (1.390; 1.307-1.478; P<.001);

    • ICU admission (1.336; 1.139-1.566; P<.001; I2, 66.643); and

    • mortality (1.276; 1.176-1.385; P<.001).

  • Asthma was not associated with an increased risk of COVID-19-related (aOR; 95% CI):

    • hospitalisation (0.873; 0.726-1.049; P=.148; I2, 85.355);

    • ICU admission (0.746; 0.545-1.020; P=.067; I2, 87.198); and

    • mortality (0.827; 0.711-0.961; P=.013; I2, 61.481).

  • In the Cox regression model, COPD (adjusted HR [aHR], 1.296; 95% CI, 1.170-1.436; P<.001; I2, 88.386), but not asthma (aHR, 0.930; 95% CI, 0.865-1.000; P=.049; I2, 64.176), was associated with an increased risk of mortality.

Limitations

  • Heterogeneity among studies.

  • Risk of bias.
     

Pardhan S, Wood S, Vaughan M, Trott M. The Risk of COVID-19 Related Hospitalsation, Intensive Care Unit Admission and Mortality in People With Underlying Asthma or COPD: A Systematic Review and Meta-Analysis. Front Med (Lausanne). 2021;8:668808. doi: 10.3389/fmed.2021.668808. PMID: 34222281.  View full text

This clinical summary originally appeared on Univadis, part of the Medscape Professional Network.

Comments

3090D553-9492-4563-8681-AD288FA52ACE
Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.
Post as:

processing....