Frailty in OA and RA Patients and the Effect of Comorbidities

Pavankumar Kamat

Disclosures

July 27, 2021

Takeaway

  • Patients with osteoarthritis (OA) and rheumatoid arthritis (RA) were more likely to have or develop prevalent and incident frailty.

  • Furthermore, common comorbidities were associated with increased prevalent frailty in patients with OA and RA.

Why this matters

  • Findings emphasise the significance of targeted interventions to prevent and manage common comorbidities in patients with OA and RA.

Study design

  • The study involved 457,561 participants (age, 40-69 years) from the UK Biobank.

  • Frailty was evaluated using a frailty index (FI; continuous) and a modified frailty phenotype (robust, pre-frail and frail).

  • The association between different comorbidities and prevalent frailty in patients with OA and RA was evaluated.

  • Funding: None.

Key results

  • Of the 457,561 participants, 4894 (1.1%) had RA and 35,884 (7.8%) had OA.

  • Patients with RA (adjusted relative risk ratio [aRRR], 10.7; 95% CI, 9.7-11.7) and OA (aRRR, 3.4; 95% CI, 3.3-3.6) were more likely to have prevalent frailty and a higher FI at baseline.

  • Considering the interaction between RA and each of the comorbidities, the attributable proportion (AP; 95% CI) between RA and stroke/transient ischaemic attack and the risk of frailty was highest (0.60; 0.38-0.82), followed by RA and depression (0.53; 0.35-0.70) and RA and congenital heart disease (CHD; 0.52; 0.36-0.68).

  • Considering the interaction between OA and each of the comorbidities, the AP (95% CI) between OA and diabetes and the risk of frailty was highest (0.49; 0.42-0.55), followed by OA and CHD (0.48; 0.41-0.55) and OA and depression (0.47; 0.41-0.53).

Limitations

  • Response rate for the UK Biobank study was low (5.5%).
     

Cook MJ, Verstappen SMM, Lunt M, O'Neill TW. Increased frailty in people with osteoarthritis and rheumatoid arthritis and the influence of co-morbidity: an analysis of the UK Biobank cohort. Arthritis Care Res (Hoboken). 2021 Jul 07 [Epub ahead of print]. doi: 10.1002/acr.24747. PMID: 34235888.  View abstract 

This clinical summary originally appeared on Univadis, part of the Medscape Professional Network.

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