Pro-Con Debate

Fibrinogen Concentrate or Cryoprecipitate for Treatment of Acquired Hypofibrinogenemia in Cardiac Surgical Patients

Nadia B. Hensley, MD; Michael A. Mazzeffi, MD, MPH, MSc, FASA


Anesth Analg. 2021;133(1):19-28. 

In This Article

Fibrinogen Concentrate Disadvantage: Lower Efficacy in Complex Cases With Long CPB Time Benefits of Cryoprecipitate Over Fibrinogen Concentrate in Cardiac Surgery

Despite the findings of the FIBRES study, cryoprecipitate may be superior in some cardiac surgical patients.[24] In the FIBRES study, the median CPB duration was 130–140 minutes, but the CPB duration is often longer in complex aortic surgery with deep hypothermic circulatory arrest or in the other combined cardiac surgery procedures. It remains unclear whether fibrinogen concentrate will have equal efficacy in these types of cases where CPB duration is 200–300 minutes.[24]