Subclinical Hypothyroidism Represents Visceral Adipose Indices, Especially in Women With Cardiovascular Risk

Meng-Ting Tsou

Disclosures

J Endo Soc. 2021;5(6) 

In This Article

Results

Baseline Characteristics According to Thyroid Functional Status

Of 1644 participants, 125 (7.6%) were SCH patients and 1519 (92.4%) were EU individuals. Sex is strongly correlated with obesity and CV risk factor, and we therefore compared the characteristics all participants according to sex (Table 1).

The SCH group comprised a greater quantity of women and older individuals than the EU group (women, SCH vs EU, 52 [41.6%] vs 441 [29.0%], P < .001; age, SCH vs EU, 52.9 ± 10.16 vs 49.54 ± 9.77, P < .001). The participants' history of smoking and diabetes was comparable, but HTN was higher in men with SCH. Minimal differences in clinical and biochemical traits were noted between the SCH and the EU groups. Significant variations in 10-year FRS were observed between men in the 2 respective groups (SCH vs EU: 15.29 ± 12.00 vs 12.30 ± 11.62, P = .03); and the incidence of intermediate and high AR10y was higher in male participants with SCH (P = .01).

Significant age discrepancies were not observed between the female participants in both groups (SCH vs EU, 53.83 ± 10.00 vs 51.44 ± 9.85, P = .10). We found that the anthropomorphic clinical indices (BMI, BRI, and CVAI) and the VAT (TAT) were higher in the women with SCH (P < .05).

Odds Ratios of Region-Specific Cardiovascular Fat Tissue and Noninvasive Visceral Adipose Indices With Risk of Subclinical Hypothyroidism

Multivariable logistic regression models showed that the ORs for SCH increased with TAT and BRI score for women in 4 models (Table 2). The independent association of TAT and BRI with SCH were stronger in female participants than their male counterparts. The adjusted model associations (OR, 95% CI) with SCH for TAT and BRI in women were 2.61 (95% CI, 1.03–6.97) and 2.04 (95% CI, 1.07–3.92) (model 4).

These association predictors were essentially unaffected by adjusting for age and lifestyle factors (models 2 and 3). After considering the impact of blood pressure, FPG, HDL-C, LDL-C, and FRS on association estimators, the OR increased by 30% in TAT and by about 10% in BRI in women (model 4).

A Comparison of the Incidence of Region-specific Cardiovascular Fat Tissue and Noninvasive Visceral Adipose Indices According to Thyroid Functional Status

Table 3 compares the participants' region-specific CV fat tissue and noninvasive visceral adipose indices. The TAT, BRI, and CVAI were higher in the women with SCH group (SCH vs EU: 5.48 ± 3.43 vs 4.24 ± 2.30; 3.69 ± 1.22 vs 3.37 ± 1.22; 83.29 ± 36.5 vs 69.29 ± 39.30, P < .05). The incidences of TAT and BRI third tertile were also higher in women with SCH (SCH vs EU, TAT third tertile, 9 [17.3%] vs 35 [7.9%], P = .04; BRI third tertile, 22 [42.3%] vs 111 [25.2%], P = .01). The incidence of ABSI third tertile was higher in men with SCH (SCH vs EU, 35 [47.9%] vs 383 [35.5%], P = .01). In the female participants, the incidence of region-specific CF fat tissue and noninvasive visceral adipose indices was marginally greater in individuals with SCH as opposed to the EU individuals.

Baseline Characteristics According to Thyroid Functional Status and Absolute Risk of Cardiovascular Event in 10 Years by Framingham Risk Score

According to FRS score, the participants with low risk and intermediate/high risk were 995 and 649 individuals, with 68 of 927 of SCH individuals and 57 of 592 of those in the EU group (Table 4). We found that the TAT, BRI, and CVAI were higher in the women with SCH group and intermediate/high CV risk (P < .05), and other indices (eg, WC) were higher in the women with SCH group (borderline statistically difference, P = .05). TAT was higher in the women with SCH group and those with low CV risk (P = .01)

Odds Ratios of Region-specific Cardiovascular Fat Tissue and Noninvasive Visceral Adipose Indices With Risk of Subclinical Hypothyroidism in Different Absolute Risks of Cardiovascular Event in 10 Years by Framingham Risk Score

Multivariable logistic regression models indicated that the ORs for SCH increased with TAT, BRI, and CVAI score for women in 3 models (Table 5). The independent association was stronger in women than in men. In the intermediate/high CV risk group, the adjusted model associations (OR, 95% CI) with SCH for TAT, BRI, and CVAI in women were 4.01 (95% CI, 1.01–6.64), 7.04 (95% CI, 1.02–11.29), and 7.81 (95% CI, 1.01–12.03) (model 3).

Even after adjusting for age and lifestyle factors, the association estimators remained essentially unchanged (model 2). When factoring in blood pressure, FPG, HDL-C, LDL-C, and FRS, the OR increased by 80% in TAT, by about 13% in BRI, and by about 50% in the CVAI for women group (model 3).

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