Neurologic Aspects of Coronavirus Disease of 2019 Infection

Catherine E. Hassett; Jennifer A. Frontera


Curr Opin Infect Dis. 2021;34(3):217-227. 

In This Article

Acute Toxic-metabolic Encephalopathy

Toxic-metabolic encephalopathy (TME) is a global, reversible cerebral dysfunction in the absence of focal neurologic deficits or structural brain disease.[34] This altered state appears to be one of the most common neurological complications among hospitalized COVID-19 patients with a wide range of incidence from 7 to 87%.[34–36] COVID-19 patients with TME diagnosis were more likely to have a longer hospital stay, less favorable discharge, and have an increased risk of mortality.[34] Etiologies of TME include infection or septic encephalopathy, hypoxia, hypercarbia, uremia, hyponatremia, or hyperinflammatory state as commonly experienced by severely affected COVID-19 patients.[29,34–37]