Erythema Nodosum: A Practical Approach and Diagnostic Algorithm

Daniela Michelle Pérez-Garza; Sonia Chavez-Alvarez; Jorge Ocampo-Candiani; Minerva Gomez-Flores


Am J Clin Dermatol. 2021;22(3):367-378. 

In This Article


Although a large percentage of patients with EN have an unknown etiology, it can be the first sign of a systemic disease in some patients. An early diagnosis is important for optimal management of the underlying disease; thus, a detailed medical history, physical examination, laboratory tests, and imaging studies should be performed during the initial work-up. The diagnostic algorithm for EN described in this study is intended to help physicians make a timely and accurate diagnosis of the underlying cause, which could be a potentially life-threatening condition, and to determine an optimal treatment strategy.