Results suggest that people with chronic pain and MS most commonly experience pain that has characteristics of nociceptive mechanisms or a mixed pain state, which can be described as a combination of nociceptive, nociplastic, and/or neuropathic pain characteristics. Pain that can be described as having purely neuropathic characteristics was relatively rare. This work highlights the need to assess pain phenotype in persons with chronic pain and MS to move toward a precision model of pain management in MS.
The National Multiple Sclerosis Society (NMSS) provided participant recruitment support by distributing study advertisements through their email listserv. The Michigan Institute for Clinical and Health Research (MICHR: NIH award number UL1TR002240) provided participant recruitment support through the UMHealthResearch.org web site. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The authors thank Shubhangi Kulkarni, MS, for her contribution in coordinating this study and collecting these data.
Pain. 2021;162(5):1426-1433. © 2021 Lippincott Williams & Wilkins