Characterizing Chronic Pain Phenotypes in Multiple Sclerosis

A Nationwide Survey Study

Anna L. Kratz; Daniel Whibley; Kevin N. Alschuler; Dawn M. Ehde; David A. Williams; Daniel J. Clauw; Tiffany J. Braley


Pain. 2021;162(5):1426-1433. 

In This Article


Results suggest that people with chronic pain and MS most commonly experience pain that has characteristics of nociceptive mechanisms or a mixed pain state, which can be described as a combination of nociceptive, nociplastic, and/or neuropathic pain characteristics. Pain that can be described as having purely neuropathic characteristics was relatively rare. This work highlights the need to assess pain phenotype in persons with chronic pain and MS to move toward a precision model of pain management in MS.