Diabetic Foot Ulcers and Osteomyelitis: Use of Biodegradable Calcium Sulfate Beads Impregnated With Antibiotics for Treatment of Multidrug-Resistant Organisms

Prashant Patil, MCh, FDFS; Rajeev Singh, MS; Apurva Agarwal, MS; Rajiv Wadhwa, MS; Aran Bal, MS, PhD; Sanjay Vaidya, MS, MCh


Wounds. 2021;33(3):70-76. 

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This study has several limitations, including its retrospective nature and lack of a control group. The main limitation of this case series is the lack of randomization of the study design. Future prospective, randomized clinical trials with a more standardized protocol are necessary to further evaluate the clinical effectiveness of the treatment reported here. Additionally, the potential for cost-benefit analysis in terms of reduced rate of admission to the hospital, reduced need for surgery, and reduced need for systemic antibiotics warrants further investigation. The duration of follow-up in this study may be insufficient to show the outcomes in all patients, which may influence recurrence or amputation rates.