Research Priorities for Coronavirus Disease 2019 in Critical Illness

The Surviving Sepsis Campaign

Craig M. Coopersmith, MD, MCCM; Massimo Antonelli, MD; Seth R. Bauer, PharmD, FCCM; Clifford S. Deutschman, MS, MD, MCCM; Laura E. Evans, MD, MSc, FCCM; Ricard Ferrer, MD, PhD; Judith Hellman, MD; Sameer Jog, MD; Jozef Kesecioglu, MD, PhD; Niranjan Kissoon, MB BS, MCCM; Ignacio Martin-Loeches, MD, PhD; Mark E. Nunnally, MD, FCCM; Hallie C. Prescott, MD, MSc; Andrew Rhodes, MB BS, MD(Res); Daniel Talmor, MD, MPH; Pierre Tissieres, MD, DSc; Daniel De Backer, MD, PhD


Crit Care Med. 2021;49(4):598-622. 

In This Article


Because of the severity of the worldwide pandemic, knowledge of COVID-19 is advancing with unprecedented speed, with over 75,000 publications in pubmed at the time of this submission. Considering the rapidity of changes in our understanding of the disease and the mandatory time lag between submission of a paper, peer review, and publication, we freely acknowledge that some of what is contained herein will be out of date by the time of publication or shortly thereafter. Nonetheless, there continue to be significant gaps in understanding of a new disease which has impacted the entire world in a way that is unique in generations. We hope this prioritization will serve as a catalyst for urgently needed research for critically ill patients with COVID-19.