Atopic eczema, psoriasis and hidradenitis suppurativa were weakly associated with chronic kidney disease (CKD), independent of obesity, cardiovascular morbidity or non-biologic nephrotoxic skin medications.
No evidence supporting this association was found in people with diabetes.
Why this matters
Findings warrant further research to elucidate the nature and temporal direction of this link, to account for other potential confounders, and explore whether targeted screening for CKD in people with inflammatory skin diseases is justified.
Researchers conducted 2 complementary analyses (case-control and cohort study) using data from the UK Clinical Practice Research Datalink.
56,602 patients with CKD stages 3-5 were matched with 268,305 control participants in the case-control study; 335,827 patients with diabetes were included in the cohort study.
Patients with CKD3-5 vs those without were more likely to have a history of (adjusted OR [aOR]; 99% CI):
atopic eczema (1.14; 1.11-1.17);
psoriasis (1.13; 1.08-1.19); and
hidradenitis suppurativa (1.49; 1.19-1.85).
CKD3-5 was associated with lower prevalence of rosacea (aOR, 0.92; 95% CI, 0.87-0.97).
Results remained similar after adjusting for hypertension and cardiovascular disease (aOR; 99% CI):
atopic eczema (1.10; 1.07-1.13);
psoriasis (1.12; 1.07-1.17); and
hidradenitis suppurativa (1.45; 1.16-1.82).
Patients with atopic eczema and psoriasis were more likely to have CKD3-5, irrespective of atopic eczema and psoriasis severity. The association was stronger in patients with more severe skin disease (Ptrend<.0001).
No association was seen between CKD3-5 incidence and atopic eczema and psoriasis in people with diabetes.
Risk of misclassification.
Risk of potential confounders.
This clinical summary originally appeared on Univadis, part of the Medscape Professional Network.
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Any views expressed above are the author's own and do not necessarily reflect the views of WebMD or Medscape.
Cite this: Sarfaroj Khan. Inflammatory Skin Diseases and CKD Risk: What’s the Link? - Medscape - Mar 23, 2021.