"Cold" Platelets, Whole Blood, and Other Uncommon Platelet Products
"Cold" platelets are platelets stored at 4°C instead of the conventional 22°C. Cold platelets are cleared from the circulation more rapidly than conventional platelets, but may have greater immediate hemostatic efficacy.[22–25] Trials of cold-stored platelets in cardiac surgery and other clinical scenarios are ongoing. Whole blood for transfusion contains red cells, plasma, and platelets; is stored cold at 4°C; and is increasingly common in civilian trauma resuscitation. Platelet counts after whole blood transfusion in bleeding patients are comparable to those obtained with balanced multicomponent resuscitation. In centers where it is available, it is common to begin resuscitation with whole blood and then switch to laboratory-guided component therapy after major bleeding is controlled. Other products also exist, such as frozen or lyophilized platelets, but these are not licensed in the United States.
Anesthesiology. 2021;134(3):471-479. © 2021 American Society of Anesthesiologists | Lippincott Williams & Wilkins