Mimics of Vasculitis

Ernest Maningding; Tanaz A. Kermani

Disclosures

Rheumatology. 2021;60(1):34-47. 

In This Article

Calciphylaxis

Calciphylaxis, or calcific uraemic arteriolopathy, is an obstructive vasculopathy thought to be caused by the presence of calcium and thrombi in small vessels, resulting in extremely painful lesions.[95] The cutaneous manifestations of violaceous subcutaneous plaques, cutaneous nodules, livedo reticularis and/or purpura, which often rapidly progress to ulcerations with black eschars, can mimic medium and small vessel vasculitis.[95–97] Common risk factors include a history of end-stage renal disease; increased calcium, phosphorus and PTH levels and warfarin use.[95,97] Biopsy is not routinely recommended due to the possibility of poor subsequent wound healing but may be helpful for unclear cases, particularly in patients without end-stage renal disease.[95]

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