Prophylactic use of concurrent dexamethasone and oral mosapride can reduce overall incidence and severity of PONV, especially postoperative nausea, as well as increase complete response rates during the first 12 h after total hip and knee arthroplasty when compared with other patients. While it seemed that oral mosapride would not provide additional effect on reducing the rate of severe PONV when compared with dexamethasone alone. Preemptive oral mosapride can also improve postoperative appetite and bowel function.
PONV: Postoperative nausea and vomiting; THA: Total hip arthroplasty; TKA: Total knee arthroplasty; ASA: American Society of Anesthesiologists; PACU: Post-anesthesia care unit; BMI: Body mass index
We thank Xiaowei Feng, M. D (Chengdu First People's Hospital, Chengdu, China) and A. Chapin Rodriguez, PhD for helpful suggestions on the manuscript. We also thank all the patients and staff who participated in this study.
The research was supported by the Post-Doctor Research Project, West China Hospital, Sichuan University (2018HXBH073); the National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University (Z2018B11); and the National Health and Family Planning Commission of the People's Republic of China program (201302007).
Availability of data and materials
The datasets used and analysed during the current study are available from the corresponding author on reasonable request.
Ethics approval and consent to participate
The study protocol was approved by the Institutional Review Board of West China Hospital, Sichuan University (2012–268), and all procedures were performed according to the Declaration of Helsinki. Written informed consent was obtained prospectively from all patients prior to surgery.
Consent for publication
BMC Anesthesiol. 2020;20(297) © 2020 BioMed Central, Ltd.