Platelet-Rich Plasma: Evolving Role in Plastic Surgery

Edward S. Chamata, M.D.; Erica L. Bartlett, M.D.; David Weir, N.P.-C.; Rod J. Rohrich, M.D.


Plast Reconstr Surg. 2021;147(1):219-230. 

In This Article

Shortcomings and Lack of Data

Ideally, universal agreement regarding preparation and administration should exist. A number of variables play a role on the ultimate effect of platelet-rich plasma on wound healing, and for this reason, little consensus exists with regard to the best method of platelet-rich plasma implementation. Some important aspects of platelet-rich plasma preparation include volume of blood collected, anticoagulant used, centrifugation speed, centrifugation time, number of spins, activating agent, and final volume of plasma. The type of problem being treated and the patient's health condition may also play a part in the treatment efficacy.

A lack of objective outcomes reporting exists in the majority of studies to date. Many studies rely on comparison of pretreatment and posttreatment photographs to measure outcomes, assessed by either a physician or an investigator, with some studies implementing the use of a blinded evaluator. Patient self-assessment and/or patient satisfaction surveys were also used in a majority of studies as a method of reporting results. More objective assessment methods include histopathologic evaluation using immunohistochemistry, skin surface analyzers to quantify wrinkles, and digital imaging analysis to measure hair growth, among other tools.[34,56,68,83] The use of objective outcome measures provides an opportunity for study reproducibility and comparison in technique.