Platelet-Rich Plasma: Evolving Role in Plastic Surgery

Edward S. Chamata, M.D.; Erica L. Bartlett, M.D.; David Weir, N.P.-C.; Rod J. Rohrich, M.D.


Plast Reconstr Surg. 2021;147(1):219-230. 

In This Article

Safety and Adverse Effects

As platelet-rich plasma is an autologous product, it is considered safe and free from communicable diseases.[105] Sterility should be confirmed; however, this is less of a concern with commercial devices, as inadvertent handling is minimized. No serious complications have been reported with the use of platelet-rich plasma. Minor complications include transient edema, bruising, erythema and crusting, all of which are injection-related.[106] Subjective feeling of skin tightness is transient. Although there is a theoretical risk of injecting platelet-rich plasma into a vessel, no such complications have been reported. There has been some literature suggesting that platelet-rich plasma can increase pigmentation in certain individuals with postinflammatory hyperpigmentation; thus, one should manage these patients with caution.[107]