Headache as a Cardinal Symptom of Coronavirus Disease 2019

A Cross-Sectional Study

Javier A. Membrilla, MD; Íñigo de Lorenzo, MD; María Sastre, MD; Javier Díaz de Terán, MD


Headache. 2020;60(10):2176-2191. 

In This Article


Headache is a very common COVID-19 symptom among patients presenting to the emergency room. Its semiological characteristics can be highly diverse, but most frequently present as holocranial or bifrontal moderate-to-severe pain with pressing quality and migraine-like features are not rare. In migraine patients, COVID-19 headache tends to last longer, is more severe and presents earlier in the course of the disease than in patients without migraine.