Genomic Screening for Malignant Hyperthermia Susceptibility

Leslie G. Biesecker, M.D.; Robert T. Dirksen, Ph.D.; Thierry Girard, M.D.; Philip M. Hopkins, M.D.; Sheila Riazi, M.D.; Henry Rosenberg, M.D.; Kathryn Stowell, Ph.D.; James Weber, Ph.D.


Anesthesiology. 2020;133(6):1277-1282. 

In This Article

Healthcare Information Systems for Real-time Support Resources for the Management of a MH Reaction and Management of At-risk Individuals

In North America, the Malignant Hyperthermia Association of the United States provides 24/7 hotline support for clinicians managing patients with a known or suspected MH reaction (similar resources are available in other countries). These valuable resources should be universally recognized and readily used, but additional resources for the identification and management of MH should be developed. Artificial intelligence–driven[22] patient monitoring and clinical decision support tools[23] within the electronic health record could be developed to support preoperative decision-making regarding test results, facilitate real-time early recognition of an MH event, and other decisions. Finally, information on MH susceptibility should be readily portable so that patients can benefit from it no matter where they receive their care.