Genomic Screening for Malignant Hyperthermia Susceptibility

Authors and Disclosures

Leslie G. Biesecker, M.D., Robert T. Dirksen, Ph.D., Thierry Girard, M.D., Philip M. Hopkins, M.D., Sheila Riazi, M.D., Henry Rosenberg, M.D., Kathryn Stowell, Ph.D. and James Weber, Ph.D.

Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, Bethesda, Maryland (L.G.B.); Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York (R.T.D.); Department Anesthesiology, University Hospital Basel, University of Basel, Switzerland (T.G.); MH Investigation Unit, University of Leeds, Leeds, United Kingdom (P.M.H.); Department of Anesthesiology and Pain Medicine, University of Toronto, Ontario, Canada (S.R.); Malignant Hyperthermia Association of the United States, Sherburne, New York (H.R.); Department of Biochemistry, Massey University, Palmerston North, New Zealand (K.S.); and Prevention Genetics, Marshfield, Wisconsin (J.W.).

Correspondence
Address correspondence to Dr. Rosenberg: President, Malignant Hyperthermia Association of the United States, Post Office Box 1069, Sherburne, New York 13460. henryrosenbergmd@gmail.com. ANESTHESIOLOGY's articles are made freely accessible to all readers on www.anesthesiology.org, for personal use only, 6 months from the cover date of the issue.

Competing Interests
Dr. Weber is the CEO and part owner of Prevention Genetics (Marshfield, Wisconsin). Dr. Biesecker reports research support from ArQule (now wholly owned by Merck, Inc., Kenilworth, New Jersey), Pfizer, Inc. (New York, New York), and honoraria from Cold Spring Harbor Laboratory (Cold Spring Harbor, New York). Dr. Riazi reports research support from Norgine Pharmaceuticals (Amsterdam, the Netherlands). The remaining authors declare no competing interests.

Appendix: Online Resources

Genetic Test Registry for RYR1 testing: https://www.ncbi.nlm.nih.gov/gtr/all/tests/?term=6261%5Bgeneid%5D. Accessed August 25, 2020.

Genetic Test Registry for CACNA1S testing: https://www.ncbi.nlm.nih.gov/gtr/all/tests/?term=779%5Bgeneid%5D. Accessed August 25, 2020.

Malignant Hyperthermia Association of the United States (MHAUS): https://www.mhaus.org. Accessed August 25, 2020.

The North American Malignant Hyperthermia Registry of MHAUS: https://anest.ufl.edu/namhr. Accessed August 25, 2020.

European Malignant Hyperthermia Group (EMHG): https://www.emhg.org. Accessed August 25, 2020.