Hirschsprung Disease: Osmosis Study Video

Rishi Desai, MD, MPH


August 28, 2020

Hirschsprung disease is a form of megacolon that occurs when part or all of the large intestine or antecedent parts of the gastrointestinal tract have no ganglion cells and therefore cannot function. During normal prenatal development, cells from the neural crest migrate into the large intestine (colon) to form the networks of nerves called the myenteric plexus (Auerbach plexus) and the submucosal plexus (Meissner plexus).

In Hirschsprung disease, the migration is not complete and part of the colon lacks these nerve bodies that regulate the activity of the colon. The affected segment of the colon cannot relax and pass stool through the colon, creating an obstruction. In most people, the disorder affects the part of the colon that is nearest the anus.

Review key aspects of etiology, diagnosis, and treatment in this short video.

For more study tools from Osmosis on Medscape, see our collection here.

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