STAT5: From Pathogenesis Mechanism to Therapeutic Approach in Acute Leukemia

Mohammad Shahjahani, PhD; Amirreza Abroun, MSc; Najmaldin Saki, PhD; Seyed Mohammad Bagher Mohammadi, MSc; Hadi Rezaeeyan, PhD


Lab Med. 2020;51(4):345-351. 

In This Article


Although much progress has been made in the identification of molecular pathways in Ph-positive ALL cells to design appropriate treatments, some patients still do not show complete response to common treatments, and disease relapse remains a challenge. It seems that the proliferation of leukemia cells and their refractoriness to apoptosis are the main factors of resistance to chemotherapy. In contrast, according to the aforementioned content, STAT5 is a vital factor in the progression and prognosis of acute leukemia (especially ALL) through its undeniable role in the proliferation of leukemic cells and the inhibition of their apoptosis, as well as inducing hTERT (a catalytic unit of telomerase complex). We hypothesize that targeting STAT5 in patients not only suppresses the proliferation of Ph-positive ALL cells but also makes these cells sensitive to chemotherapy via decreasing the expression of hTERT. Confirmation of this possibility will require further studies in the future.