Review Article

Bugs, Inflammation and Mood—A Microbiota-based Approach to Psychiatric Symptoms in Inflammatory Bowel Diseases

Anne K. Thomann; Joyce W. Y. Mak; Jing Wan Zhang; Torsten Wuestenberg; Matthias P. Ebert; Joseph J. Y. Sung; Çharles N. Bernstein; Wolfgang Reindl; Siew C. Ng


Aliment Pharmacol Ther. 2020;52(2):247-266. 

In This Article


The association between IBD and psychiatric co-morbidities is well established and psychiatric symptoms not only affect the quality of life but also the course of disease in patients with IBD. Both IBD and mental disorders are associated with distinct gut microbial alterations. Preclinical studies have shown a mediating role of gut microbiota in intestinal inflammation and anxiety, depression and stress, thus targeting the gut microbiota may represent a useful therapeutic approach for the treatment of psychiatric co-morbidities in IBD. Future research should aim at improving our knowledge about the role of the microbiota-gut-brain-axis in IBD to improve personalised and holistic IBD treatment.