The association between IBD and psychiatric co-morbidities is well established and psychiatric symptoms not only affect the quality of life but also the course of disease in patients with IBD. Both IBD and mental disorders are associated with distinct gut microbial alterations. Preclinical studies have shown a mediating role of gut microbiota in intestinal inflammation and anxiety, depression and stress, thus targeting the gut microbiota may represent a useful therapeutic approach for the treatment of psychiatric co-morbidities in IBD. Future research should aim at improving our knowledge about the role of the microbiota-gut-brain-axis in IBD to improve personalised and holistic IBD treatment.
AKT was supported by TRAPS-programme of the Medical Faculty Mannheim, Germany and the German Research Foundation (DFG TH 2341/2-1), WR was supported by the German Research Foundation (DFG GRK2350 and RE 2706/2-1).
Declaration of personal interests
Guarantor of the article
Prof. Siew C. Ng.
All authors approved the final version of the article, including the authorship list.
Aliment Pharmacol Ther. 2020;52(2):247-266. © 2020 Blackwell Publishing