Systematic Review With Meta-analysis

Efficacy and Safety of Treatments for Opioid-induced Constipation

Priya Vijayvargiya; Michael Camilleri; Pooja Vijayvargiya; Patricia Erwin; M. Hassan Murad


Aliment Pharmacol Ther. 2020;52(1):37-53. 

In This Article


This systematic review and meta-analysis has shown that therapeutic response in opioid-induced constipation is best achieved with the PAMORAs, methylnaltrexone, naloxegol and naldemidine, with low risk of serious adverse events or opioid withdrawal.