The Reemergence of Ketamine for Treatment in Critically Ill Adults

Kimberly P. Hurth, PharmD, BCCCP; Anthony Jaworski, PharmD, BCCCP; Kristen B. Thomas, PharmD, BCPS; William B. Kirsch, PharmD, BCPS; Michael A. Rudoni, PharmD, BCPS, BCCCP; Kevin M. Wohlfarth, PharmD, BCPS, BCCCP, BCCP


Crit Care Med. 2020;48(6):899-911. 

In This Article


As our understanding of ketamine expands, so does its role in the management of critically ill patients (Table 3). This review sought to summarize the use of ketamine in various disease states encountered in the ICU and ED, although most publications were limited by small sample sizes retrospective design. Further prospective, randomized controlled trials with standardized dosing and adjunctive therapies are needed to support ketamine use in these disease states for the critically ill population.[50–57]