The Optimal Dose of Succinylcholine for Rapid Sequence Induction

A Systematic Review and Meta-analysis of Randomized Trials

Alessandro Putzu; Martin R. Tramèr; Maxim Giffa; Christoph Czarnetzki


BMC Anesthesiol. 2020;20(54) 

In This Article


With succinylcholine regimens ≤0.5 mg kg− 1, excellent intubating conditions are less likely compared with the gold standard regimen, 1 mg kg− 1. With 0.3 and 0.4 mg kg− 1, unacceptable intubating conditions are more common. With regimens below 1 mg kg− 1, apnoea times are shorter. With 2 mg kg− 1, excellent intubating conditions seem to be more likely but the database is weak, and apnoea times remain unknown. Small information size and strong statistical heterogeneity limit the certainty of the evidence.