Cerebral Hemorrhage and Alcohol Exposure: A Review

Jialing Peng; Hongxuan Wang; Xiaoming Rong; Lei He; L Xiangpen; Qingy Shen; Ying Peng


Alcohol Alcohol. 2020;55(1):20-27. 

In This Article

Alcohol Consumption and Outcome of ICH

Figure 1 shows some processes underlying the harmful effect of alcohol pretreatment on acute ICH: microglial activation and cascade response of inflammatory cytokine exerted inflammatory injury (Pascual et al., 2017), matrix metalloproteinase (MMPs) activation-induced blood–brain barrier (BBB) breakdown (Cheng et al., 2018), hypotension (Rekik et al., 2002) caused by blunted baroreflex and acid–base imbalance (Phelan et al., 2002) and so on. However, it is interesting that alcohol pretreatment has no significant influence on hematologic system during acute ICH (Cheng et al., 2018). It is well accepted that chronic alcohol consumption is associated with the severity of ICH via enlargement of ICH volume, higher short-term (90 days) mortality rate and poor functional outcome (Fujii et al., 1998; Han et al., 2016). Otherwise, chronic alcohol use combined with a low low density lipoproteinlevel would lead to an exaggeration of clinical outcome of ICH (Pletsch et al., 2014). For long-term ICH survivors, chronic alcohol abuse is demonstrated as independent predictor of post-ICH seizures which are likely associated with pneumonia, mechanical ventilation and handicap and so on (Bateman et al., 2007).

Figure 1.

The impact of alcohol pretreatment on acute ICH.