Before the routine use of Hib vaccines, incidence of H. influenzae meningitis among American Indian/Alaska Native (AI/AN) infants peaked at a younger age (4–6 months) than it did among other U.S. infant populations (6–7 months). Vaccination with a primary series of a Hib vaccine that contains PRP-OMP is preferred for AI/AN infants to provide early protection because these vaccines can provide a protective antibody response after the first dose. Data on antibody response after the first dose of DTaP-IPV-Hib-HepB in AI/AN infants are not currently available; therefore, DTaP-IPV-Hib-HepB does not have a preferential recommendation for AI/AN infants at this time. If data on antibody response after the first dose of DTaP-IPV-Hib-HepB become available, ACIP will re-evaluate the preferential language for the Hib component for AI/AN infants.
Laura Hammitt, Center for American Indian Health, Johns Hopkins Bloomberg School of Public Health.
ACIP Combination Vaccines Work Group
Chair: Kelly L. Moore; Members: Jillian Doss-Walker, Phil Griffin, Jennifer L. Hamilton, Veronica McNally, Sarah McQueen, Sean T. O'Leary, Elizabeth Rausch-Phung, Ann Schwartz, Patsy Stinchfield, Thomas Weiser; CDC Contributors: Anna Acosta, Mike Bruce, Fiona P. Havers, Andrew Kroger, Pedro Moro, Janell A. Routh, Sarah Schillie, Rosalyn Singleton, Cindy Weinbaum, JoEllen Wolicki.
Morbidity and Mortality Weekly Report. 2020;69(5):136-139. © 2020 Centers for Disease Control and Prevention (CDC)